PRIMA-1 MET

Name PRIMA-1 MET
Supplier Tocris Bioscience
Catalog 1862
Prices $139.00
Sizes 10 mg
Cas Number 5291-32-7
Chemical Name 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Formula C10H17NO3
Molecular Weight 199.25
Purity >98 %
Description Methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
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Product References

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. - PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

Bykov VJ, Zache N, Stridh H, Westman J, Bergman J, Selivanova G, Wiman KG. Oncogene. 2005 May 12;24(21):3484-91.

PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. - PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.

Shen J, Vakifahmetoglu H, Stridh H, Zhivotovsky B, Wiman KG. Oncogene. 2008 Nov 20;27(51):6571-80.

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 - PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5

Stuber G, Flaberg E, Petranyi G, Otvos R, Rokaeus N, Kashuba E, Wiman KG, Klein G, Szekely L. Mol Cancer. 2009 Mar 26;8:23.