Prion Protein 106-126 (human)

• Supplier: Tocris Bioscience
• Catalog: 0830
• Prices: $225.00
• Sizes: 1 mg
• Cas Number: 148439-49-0
• Formula: C80H138N26O24S2
• Molecular Weight: 1912.26
• Description: Prion peptide fragment that shares many physiochemical features with PrP Sc . Exhibits neurotoxicity caused by amplification of PrP C -associated signaling responses and induces NF- κ B-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β -sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro .

Product References

Neurotoxicity of a prion protein fragment. - Neurotoxicity of a prion protein fragment.

Forloni G, Angeretti N, Chiesa R, Monzani E, Salmona M, Bugiani O, Tagliavini F. Nature. 1993 Apr 8;362(6420):543-6.

Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes - Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes

Pietri M, Caprini A, Mouillet-Richard S, Pradines E, Ermonval M, Grassi J, Kellermann O, Schneider B. J Biol Chem. 2006 Sep 22;281(38):28470-9. Epub 2006 Jul 24.

p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in - p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in

Bai Y, Li Q, Yang J, Zhou X, Yin X, Zhao D. Neurosci Res. 2008 Sep;62(1):9-14.