Pristimerin

Name Pristimerin
Supplier Tocris Bioscience
Catalog 3491
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1258-84-0
Chemical Name (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester
Formula C30H40O4
Molecular Weight 464.64
Purity >99 %
Description Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK αβ . Displays antitumor, anti-inflammatory and antimicrobial activities.
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Product References

Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) - Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose)

Byun JY, Kim MJ, Eum DY, Yoon CH, Seo WD, Park KH, Hyun JW, Lee YS, Lee JS, Yoon MY, Lee SJ. Mol Pharmacol. 2009 Oct;76(4):734-44.

Discovery of potent and reversible monoacylglycerol lipase inhibitors. - Discovery of potent and reversible monoacylglycerol lipase inhibitors.

King AR, Dotsey EY, Lodola A, Jung KM, Ghomian A, Qiu Y, Fu J, Mor M, Piomelli D. Chem Biol. 2009 Oct 30;16(10):1045-52.

Identification of a potent natural triterpenoid inhibitor of proteosome - Identification of a potent natural triterpenoid inhibitor of proteosome

Tiedemann RE, Schmidt J, Keats JJ, Shi CX, Zhu YX, Palmer SE, Mao X, Schimmer AD, Stewart AK. Blood. 2009 Apr 23;113(17):4027-37.