Proglumide sodium salt

Name Proglumide sodium salt
Supplier Tocris Bioscience
Catalog 2835
Prices $59.00
Sizes 50 mg
Function Type Antagonist
Cas Number 99247-33-3
Chemical Name 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoicacidsodiumsalt
Formula C18H25N2NaO4
Molecular Weight 356.39
Purity >99 %
Description Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.
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Product References

Proglumide and benzotript: members of a different class of cholecystokinin - Proglumide and benzotript: members of a different class of cholecystokinin

Hahne WF, Jensen RT, Lemp GF, Gardner JD. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6304-8.

In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase - In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase

Iwamoto Y, Nakamura R, Akanuma Y. Gastroenterol Jpn. 1984 Feb;19(1):53-8.

Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human - Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human

Mauss S, Niederau C, Hengels KJ. Anticancer Res. 1994 Jan-Feb;14(1A):215-20.