ProTx I

• Supplier: Tocris Bioscience
• Catalog: 5500
• Prices: $209.00
• Sizes: 100 µg
• Function Type: Blocker
• Cas Number: 484598-35-8
• Formula: C171H245N53O47S6
• Molecular Weight: 3987.51
• Description: Selective Ca V 3.1 channel blocker (IC 50 values are 0.2 and 31.8 μ M for hCa V 3.1 and hCa V 3.2 respectively). Also reversibly inhibits Na V 1.8 and blocks K V 2.1 channels.

Product References

Two tarantula peptides inhibit activation of multiple sodium channels. - Two tarantula peptides inhibit activation of multiple sodium channels.

Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM, Bogusky MJ, Mehl JT, Cohen CJ, Smith MM. Biochemistry. 2002 Dec 17;41(50):14734-47.

Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ - Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+

Ohkubo T, Yamazaki J, Kitamura K. J Pharmacol Sci. 2010;112(4):452-8. Epub 2010 Mar 30.

T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in - T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in

Ohkubo T, Yamazaki J. Int J Oncol. 2012 Jul;41(1):267-75.