ProTx II

• Supplier: Tocris Bioscience
• Catalog: 4665
• Prices: $149.00
• Sizes: 100 µg
• Function Type: Blocker
• Cas Number: 484598-36-9
• Formula: C168H250N46O41S8
• Molecular Weight: 3826.59
• Description: Selective Na V 1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.

Product References

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: - Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5:

Smith JJ, Cummins TR, Alphy S, Blumenthal KM. J Biol Chem. 2007 Apr 27;282(17):12687-97. Epub 2007 Mar 5.

Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. - Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.

Edgerton GB, Blumenthal KM, Hanck DA. Toxicon. 2008 Sep 1;52(3):489-500.

ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action - ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action

Schmalhofer WA, Calhoun J, Burrows R, Bailey T, Kohler MG, Weinglass AB, Kaczorowski GJ, Garcia ML, Koltzenburg M, Priest BT. Mol Pharmacol. 2008 Nov;74(5):1476-84.