ProTx III

• Supplier: Tocris Bioscience
• Catalog: 4023
• Prices: $229.00
• Sizes: 100 µg
• Function Type: Blocker
• Formula: C162H246N52O43S6
• Molecular Weight: 3802.41
• Description: Potent Na v 1.7 blocker (IC 50 = 2.5 nM). Also inhibits Na v 1.1, Na v 1.2, Na v 1.3 and Na v 1.6 in the nanomolar range. Exhibits no effects on Ca v channels or nAChR at 5 μ M. Demonstrates analgesic activity in vivo ; antagonizes effects of scorpion-venom toxin OD1 at Na v 1.7.

Product References

The H3 receptor protean agonist proxyfan enhances the expression of fear memory - The H3 receptor protean agonist proxyfan enhances the expression of fear memory

Baldi E, Bucherelli C, Schunack W, Cenni G, Blandina P, Passani MB. Neuropharmacology. 2005 Feb;48(2):246-51.

G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for - G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for

Krueger KM, Witte DG, Ireland-Denny L, Miller TR, Baranowski JL, Buckner S, Milicic I, Esbenshade TA, Hancock AA. J Pharmacol Exp Ther. 2005 Jul;314(1):271-81. Epub 2005 Apr 8.