Psalmotoxin 1

• Supplier: Tocris Bioscience
• Catalog: 4569
• Prices: $235.00
• Sizes: 100 µg
• Function Type: Blocker
• Formula: C200H312N62O57S6
• Molecular Weight: 4689.41
• Description: Potent and selective acid-sensing ion channel 1a (ASIC1a) blocker (IC 50 = 0.9 nM). Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and K V 2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.

Product References

Structure and allosteric effects of low-molecular-weight activators on the - Structure and allosteric effects of low-molecular-weight activators on the

Hindie V, Stroba A, Zhang H, Lopez-Garcia LA, Idrissova L, Zeuzem S, Hirschberg D, Schaeffer F, Jorgensen TJ, Engel M, Alzari PM, Biondi RM. Nat Chem Biol. 2009 Oct;5(10):758-64.

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase - 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase

Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Frohner W, Hartmann RW, Biondi RM, Engel M. J Med Chem. 2009 Aug 13;52(15):4683-93.

Elastic network model of allosteric regulation in protein kinase PDK1. - Elastic network model of allosteric regulation in protein kinase PDK1.

Williams G. BMC Struct Biol. 2010 May 25;10:11.

Reprogramming of human primary somatic cells by OCT4 and chemical compounds. - Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

Zhu S, Li W, Zhou H, Wei W, Ambasudhan R, Lin T, Kim J, Zhang K, Ding S. Cell Stem Cell. 2010 Dec 3;7(6):651-5.