PSB 11 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2010
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 453591-58-7
• Chemical Name: (8R)-8-Ethyl-1,4,7,8-tetrahydro-4-5H-imidazo[2,1-i]purin-5-onehydrochloride
• Formula: C16H17N5O.HCl
• Molecular Weight: 331.8
• Purity: >98 %
• Description: Potent and selective antagonist for the human adenosine A 3 receptor, with low affinity for the rat A 3 receptor (K i values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A 1 and A 2A receptors (K i values are 4.1 and 3.3 μ M respectively) and > 180-fold selectivity over rat A 1 , rat A 2A and mouse A 2B receptors. Acts as an inverse agonist in the [ 35 S]GTP γ S binding assay in hA 3 -CHO cells (IC 50 = 36 nM).

Product References

Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine - Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine

Muller CE, Thorand M, Qurishi R, Diekmann M, Jacobson KA, Padgett WL, Daly JW. J Med Chem. 2002 Aug 1;45(16):3440-50.

Medicinal chemistry of adenosine A3 receptor ligands. - Medicinal chemistry of adenosine A3 receptor ligands.

Muller CE. Curr Top Med Chem. 2003;3(4):445-62.

2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and - 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and

Ozola V, Thorand M, Diekmann M, Qurishi R, Schumacher B, Jacobson KA, Muller CE. Bioorg Med Chem. 2003 Feb 6;11(3):347-56.