PSB 1115

• Supplier: Tocris Bioscience
• Catalog: 4333
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 152529-79-8
• Chemical Name: 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonicacid
• Formula: C14H14N4O5S
• Molecular Weight: 350.35
• Purity: >98 %
• Description: Highly selective, water-soluble, human A 2B adenosine receptor antagonist. K i values are 53.4, > 10000 and > 10000 nM at human A 2B , A 1 and A 3 receptors respectively. Also selective versus rat A 1 and A 2A receptors (K i values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo .

Product References

8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor - 8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor

Muller CE, Sandoval-Ramirez J, Schobert U, Geis U, Frobenius W, Klotz KN. Bioorg Med Chem. 1998 Jun;6(6):707-19.

1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective - 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective

Hayallah AM, Sandoval-Ramirez J, Reith U, Schobert U, Preiss B, Schumacher B, Daly JW, Muller CE. J Med Chem. 2002 Mar 28;45(7):1500-10.

Antinociceptive effects of novel A2B adenosine receptor antagonists. - Antinociceptive effects of novel A2B adenosine receptor antagonists.

Abo-Salem OM, Hayallah AM, Bilkei-Gorzo A, Filipek B, Zimmer A, Muller CE. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66. Epub 2003 Oct 16.

Preparation, properties, reactions, and adenosine receptor affinities of - Preparation, properties, reactions, and adenosine receptor affinities of

Yan L, Muller CE. J Med Chem. 2004 Feb 12;47(4):1031-43.