PSC 833

• Supplier: Tocris Bioscience
• Catalog: 3198
• Prices: $225.00
• Sizes: 1 mg
• Function Type: Modulator
• Cas Number: 121584-18-7
• Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
• Formula: C63H111N11O12
• Molecular Weight: 1214.62
• Purity: >98 %
• Description: P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Product References

Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in - Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in

Song S, Suzuki H, Terasaki T, Lemaire M, Sugiyama Y. J Pharmacol Exp Ther. 1998 Dec;287(3):963-8.

Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct - Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct

Goda K, Fenyvesi F, Bacso Z, Nagy H, Marian T, Megyeri A, Krasznai Z, Juhasz I, Vecsernyes M, Szabo G Jr. J Pharmacol Exp Ther. 2007 Jan;320(1):81-8. Epub 2006 Oct 18.

Quantitation of doxorubicin uptake, efflux, and modulation of multidrug - Quantitation of doxorubicin uptake, efflux, and modulation of multidrug

Shen F, Chu S, Bence AK, Bailey B, Xue X, Erickson PA, Montrose MH, Beck WT, Erickson LC. J Pharmacol Exp Ther. 2008 Jan;324(1):95-102. Epub 2007 Oct 18.

Dynamic assessment of mitoxantrone resistance and modulation of multidrug - Dynamic assessment of mitoxantrone resistance and modulation of multidrug

Shen F, Bailey BJ, Chu S, Bence AK, Xue X, Erickson P, Safa AR, Beck WT, Erickson LC. J Pharmacol Exp Ther. 2009 Aug;330(2):423-9.