PSI

• Supplier: Tocris Bioscience
• Catalog: 1790
• Prices: $199.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 158442-41-2
• Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide
• Formula: C32H50N4O8
• Molecular Weight: 618.77
• Purity: >90 %
• Description: Proteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. Causes dopaminergic cell death in vitro . Prevents activation of NF- κ B in response to TNF- α and okadaic acid (Cat. No. 1136) by inhibiting I κ B- α degradation. Also inhibits NO production by LPS-activated macrophages.

Product References

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly - A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly

Traenckner EB, Wilk S, Baeuerle PA. EMBO J. 1994 Nov 15;13(22):5433-41.

An immunohistochemical and stereological analysis of PSI-induced nigral neuronal - An immunohistochemical and stereological analysis of PSI-induced nigral neuronal

Bukhatwa S, Iravani MM, Zeng BY, Cooper JD, Rose S, Jenner P. J Neurochem. 2009 Apr;109(1):52-9.