Psora 4

Name Psora 4
Supplier Tocris Bioscience
Catalog 5321
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 724709-68-6
Chemical Name 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
Formula C21H18O4
Molecular Weight 334.37
Purity >99 %
Description Potent K V 1.3 channel blocker (EC 50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related K V 1 channels (K V 1, K V 2, K V 4 and K V 7); exhibits activity at K V 1.5 (IC 50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC 50 values are 25 and 60 nM respectively).
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Product References

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. - Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hansel W, Chandy KG. Mol Pharmacol. 2004 Jun;65(6):1364-74.

Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of - Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of

Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hansel W, Wulff H. Mol Pharmacol. 2005 Nov;68(5):1254-70. Epub 2005 Aug 11.

Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma - Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma

Li Y, Wang P, Xu J, Desir GV. Am J Physiol Cell Physiol. 2006 Feb;290(2):C345-51.