PTAC oxalate

• Supplier: Tocris Bioscience
• Catalog: 4039
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Cas Number: 201939-40-4
• Chemical Name: (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octaneoxalate
• Formula: C12H19N3S2.C2H2O4
• Molecular Weight: 359.46
• Purity: >98 %
• Description: Muscarinic receptor ligand. Displays partial agonist activity at M 2 and M 4 receptors; exhibits antagonist effects at M 1 , M 3 and M 5 receptors (K i values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.

Product References

Unexpected antipsychotic-like activity with the muscarinic receptor ligand - Unexpected antipsychotic-like activity with the muscarinic receptor ligand

Bymaster FP, Shannon HE, Rasmussen K, Delapp NW, Mitch CH, Ward JS, Calligaro DO, Ludvigsen TS, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P, Fink-Jensen A. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19.

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, - Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics,

Shannon HE, Hart JC, Bymaster FP, Calligaro DO, DeLapp NW, Mitch CH, Ward JS, Fink-Jensen A, Sauerberg P, Jeppesen L, Sheardown MJ, Swedberg MD. J Pharmacol Exp Ther. 1999 Aug;290(2):901-7.

Towards a muscarinic hypothesis of schizophrenia. - Towards a muscarinic hypothesis of schizophrenia.

Raedler TJ, Bymaster FP, Tandon R, Copolov D, Dean B. Mol Psychiatry. 2007 Mar;12(3):232-46. Epub 2006 Dec 5.