PTIQ

• Supplier: Tocris Bioscience
• Catalog: 5191
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1032822-42-6
• Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
• Formula: C13H17NO3
• Molecular Weight: 235.28
• Purity: >98 %
• Description: Potent inhibitor of MMP-3 expression (IC 50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

Product References

Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in - Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in

Seo JW, Srisook E, Son HJ, Hwang O, Cha YN, Chi DY. Eur J Med Chem. 2008 Jun;43(6):1160-70. Epub 2007 Sep 22.

A novel compound PTIQ protects the nigral dopaminergic neurones in an animal - A novel compound PTIQ protects the nigral dopaminergic neurones in an animal

Son HJ, Lee JA, Shin N, Choi JH, Seo JW, Chi DY, Lee CS, Kim EM, Choe H, Hwang O. Br J Pharmacol. 2012 Apr;165(7):2213-27.