PU H71

• Supplier: Tocris Bioscience
• Catalog: 4700
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 873436-91-0
• Chemical Name: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
• Formula: C18H21IN6O2S
• Molecular Weight: 512.37
• Purity: >98 %
• Description: Potent inhibitor of heat shock protein 90 (Hsp90) (IC 50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC 50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

Product References

Identification of potent water soluble purine-scaffold inhibitors of the heat - Identification of potent water soluble purine-scaffold inhibitors of the heat

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. J Med Chem. 2006 Jan 12;49(1):381-90.

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living - Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living

Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS. Cancer Res. 2008 Jan 1;68(1):216-26.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete - Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: