( Z )-Pugnac

• Supplier: Tocris Bioscience
• Catalog: 3104
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 132489-69-1
• Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
• Formula: C15H19N3O7
• Molecular Weight: 353.33
• Purity: >99 %
• Description: O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.

Product References

Purification and characterization of an O-GlcNAc selective - Purification and characterization of an O-GlcNAc selective

Dong DL, Hart GW. J Biol Chem. 1994 Jul 29;269(30):19321-30.

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development - O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development

Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ. J Biol Chem. 2005 Jul 8;280(27):25313-22. Epub 2005 Mar 28.

Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. - Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.

Perreira M, Kim EJ, Thomas CJ, Hanover JA. Bioorg Med Chem. 2006 Feb 1;14(3):837-46. Epub 2005 Oct 7.