Purmorphamine

Name Purmorphamine
Supplier Tocris Bioscience
Catalog 3384
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 483367-10-8
Chemical Name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Formula C31H32N6O2
Molecular Weight 520.62
Purity >98 %
Description Smoothened (Smo) receptor agonist (EC 50 ~ 1 μ M). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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Product References

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal - A small molecule with osteogenesis-inducing activity in multipotent mesenchymal

Wu X, Ding S, Ding Q, Gray NS, Schultz PG. J Am Chem Soc. 2002 Dec 11;124(49):14520-1.

Purmorphamine induces osteogenesis by activation of the hedgehog signaling - Purmorphamine induces osteogenesis by activation of the hedgehog signaling

Wu X, Walker J, Zhang J, Ding S, Schultz PG. Chem Biol. 2004 Sep;11(9):1229-38.

Purmorphamine activates the Hedgehog pathway by targeting Smoothened. - Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK. Nat Chem Biol. 2006 Jan;2(1):29-30. Epub 2005 Nov 20.