Purvalanol A

• Supplier: Tocris Bioscience
• Catalog: 4922
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 212844-53-6
• Chemical Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
• Formula: C19H25ClN6O
• Molecular Weight: 388.9
• Purity: >98 %
• Description: Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Product References

Exploiting chemical libraries, structure, and genomics in the search for kinase - Exploiting chemical libraries, structure, and genomics in the search for kinase

Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. Science. 1998 Jul 24;281(5376):533-8.

ATP-site directed inhibitors of cyclin-dependent kinases. - ATP-site directed inhibitors of cyclin-dependent kinases.

Gray N, Detivaud L, Doerig C, Meijer L. Curr Med Chem. 1999 Sep;6(9):859-75.

Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase - Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase

Villerbu N, Gaben AM, Redeuilh G, Mester J. Int J Cancer. 2002 Feb 20;97(6):761-9.

The specificities of protein kinase inhibitors: an update. - The specificities of protein kinase inhibitors: an update.

Bain J, McLauchlan H, Elliott M, Cohen P. Biochem J. 2003 Apr 1;371(Pt 1):199-204.