3-pyr-Cytisine

• Supplier: Tocris Bioscience
• Catalog: 3751
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 948027-43-8
• Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3-pyridinyl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
• Formula: C16H17N3O
• Molecular Weight: 267.33
• Purity: >98 %
• Description: High affinity α 4 β 2 partial agonist (K i values are 0.91, 119 and 1100 nM for α 4 β 2, α 3 β 4 and α 7 receptors respectively). Shows little activity at α 3 β 4 and α 7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy.

Product References

Cytisine-based nicotinic partial agonists as novel antidepressant compounds. - Cytisine-based nicotinic partial agonists as novel antidepressant compounds.

Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gundisch D, Picciotto MR. J Pharmacol Exp Ther. 2009 Apr;329(1):377-86.

Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine - Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine

Papke RL, Wecker L, Stitzel JA. J Pharmacol Exp Ther. 2010 May;333(2):501-18.