Pyridostatin pentahydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4125
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamidepentahydrochloride
• Formula: C31H32N8O5.5HCl
• Molecular Weight: 778.94
• Purity: >98 %
• Description: Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (K d = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Product References

Small-molecule-mediated G-quadruplex isolation from human cells. - Small-molecule-mediated G-quadruplex isolation from human cells.

Muller S, Kumari S, Rodriguez R, Balasubramanian S. Nat Chem. 2010 Dec;2(12):1095-8.

A single-molecule platform for investigation of interactions between - A single-molecule platform for investigation of interactions between

Koirala D, Dhakal S, Ashbridge B, Sannohe Y, Rodriguez R, Sugiyama H, Balasubramanian S, Mao H. Nat Chem. 2011 Aug 28;3(10):782-7.

Small-molecule-induced DNA damage identifies alternative DNA structures in human - Small-molecule-induced DNA damage identifies alternative DNA structures in human

Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP. Nat Chem Biol. 2012 Feb 5;8(3):301-10.