Pyrimethamine

• Supplier: Tocris Bioscience
• Catalog: 2478
• Prices: $65.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 58-14-0
• Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
• Formula: C12H13ClN4
• Molecular Weight: 248.71
• Purity: >99 %
• Description: Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Product References

Competitive inhibition of folate absorption by dihydrofolate reductase - Competitive inhibition of folate absorption by dihydrofolate reductase

Zimmerman J, Selhub J, Rosenberg IH. Am J Clin Nutr. 1987 Sep;46(3):518-22.

Potent and specific inhibition of mMate1-mediated efflux of type I organic - Potent and specific inhibition of mMate1-mediated efflux of type I organic

Ito S, Kusuhara H, Kuroiwa Y, Wu C, Moriyama Y, Inoue K, Kondo T, Yuasa H, Nakayama H, Horita S, Sugiyama Y. J Pharmacol Exp Ther. 2010 Apr;333(1):341-50.