Pyrintegrin

• Supplier: Tocris Bioscience
• Catalog: 3918
• Prices: $319.00
• Sizes: 10 mg
• Cas Number: 1228445-38-2
• Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
• Formula: C23H25N5O3S
• Molecular Weight: 451.54
• Purity: >98 %
• Description: Enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.

Product References

Revealing a core signaling regulatory mechanism for pluripotent stem cell - Revealing a core signaling regulatory mechanism for pluripotent stem cell

Xu Y, Zhu X, Hahm HS, Wei W, Hao E, Hayek A, Ding S. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8129-34. doi:

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. - A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.

Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. J Am Soc Nephrol. 2015 Apr 9. pii: ASN.2014090859.