Pyroxamide

• Supplier: Tocris Bioscience
• Catalog: 4978
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 382180-17-8
• Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
• Formula: C13H19N3O3
• Molecular Weight: 265.31
• Purity: >98 %
• Description: Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo . Induces p21/WAF1 expression in tumor cells.

Product References

Inhibition of transformed cell growth and induction of cellular differentiation - Inhibition of transformed cell growth and induction of cellular differentiation

Butler LM, Webb Y, Agus DB, Higgins B, Tolentino TR, Kutko MC, LaQuaglia MP, Drobnjak M, Cordon-Cardo C, Scher HI, Breslow R, Richon VM, Rifkind RA, Marks PA. Clin Cancer Res. 2001 Apr;7(4):962-70.

Inhibitors of human histone deacetylase: synthesis and enzyme and cellular - Inhibitors of human histone deacetylase: synthesis and enzyme and cellular

Remiszewski SW, Sambucetti LC, Atadja P, Bair KW, Cornell WD, Green MA, Howell KL, Jung M, Kwon P, Trogani N, Walker H. J Med Chem. 2002 Feb 14;45(4):753-7.

Chemical phylogenetics of histone deacetylases. - Chemical phylogenetics of histone deacetylases.

Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.