QNZ 46

• Supplier: Tocris Bioscience
• Catalog: 5055
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1237744-13-6
• Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoicacid
• Formula: C24H17N3O6
• Molecular Weight: 443.41
• Purity: >98 %
• Description: NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC 50 values are 3, 6, 229, and >300, >300 μ M for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.

Product References

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D - Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D

Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Brauner-Osborne H, Liotta DC, Traynelis SF. J Med Chem. 2010 Aug 12;53(15):5476-90.

Structural and mechanistic determinants of a novel site for noncompetitive - Structural and mechanistic determinants of a novel site for noncompetitive

Hansen KB, Traynelis SF. J Neurosci. 2011 Mar 9;31(10):3650-61.