| Name | QO 58 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4801 |
| Prices | $179.00, $745.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 1259536-62-3 |
| Chemical Name | 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Formula | C18H8Cl2F4N4O |
| Molecular Weight | 443.18 |
| Purity | >98 % |
| Description | K v 7 channel opener (EC 50 values are 0.6, 1.0, 5.2 and 7.0 μ M for K v 7.4, K v 7.2, K v 7.3/7.5 and K v 7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model. |
| Supplier Page | Shop |
Emre N, Coleman R, Ding S. Curr Opin Chem Biol. 2007 Jun;11(3):252-8. Epub 2007 May 10.
Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. Epub 2007 Apr 25.