L-Quisqualic acid

• Supplier: Tocris Bioscience
• Catalog: 0629
• Prices: $89.00, $189.00, $765.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 52809-07-1
• Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoicacid
• Formula: C5H7N3O5
• Molecular Weight: 189.13
• Purity: >99 %
• Description: Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .

Product References

(S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor. - (S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor.

Porter RH, Roberts PJ, Jane DE, Watkins JC. Br J Pharmacol. 1992 Jul;106(3):509-10.

Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) - Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6)

Schulte MK, Roon RJ, Chalmers DJ, Sunter DC, Koerner JF. Brain Res. 1994 Jun 27;649(1-2):203-7.

Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to - Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to

Littman L, Chase LA, Renzi M, Garlin AB, Koerner JF, Johnson RL, Robinson MB. Neuropharmacology. 1995 Aug;34(8):829-41.