QX 314 bromide

• Supplier: Tocris Bioscience
• Catalog: 1043
• Prices: $115.00
• Sizes: 100 mg
• Function Type: Blocker
• Cas Number: 24003-58-5
• Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammoniumbromide
• Formula: C16H27N2OBr
• Molecular Weight: 343.31
• Purity: >99 %
• Description: Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

Product References

The inhibition of sodium currents in myelinated nerve by quaternary derivatives - The inhibition of sodium currents in myelinated nerve by quaternary derivatives

Strichartz GR. J Gen Physiol. 1973 Jul;62(1):37-57.

QX-314 blocks the potassium but not the sodium-dependent component of the opiate - QX-314 blocks the potassium but not the sodium-dependent component of the opiate

Alreja M, Aghajanian GK. Brain Res. 1994 Mar 14;639(2):320-4.

Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in - Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in

Perkins KL, Wong RK. J Neurophysiol. 1995 Feb;73(2):911-5.

Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal - Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal

Talbot MJ, Sayer RJ. J Neurophysiol. 1996 Sep;76(3):2120-4.