| Name | R 268712 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4885 |
| Prices | $235.00, $965.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 879487-87-3 |
| Chemical Name | 4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
| Formula | C20H18FN5O |
| Molecular Weight | 363.39 |
| Purity | >98 % |
| Description | Potent and selective inhibitor of the TGF- β type I receptor/ALK5 (IC 50 = 2.5 nM). Exhibits ~5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable. |
| Supplier Page | Shop |