R 568 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5288
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 177172-49-5
• Chemical Name: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
• Formula: C18H22ClNO.HCl
• Molecular Weight: 340.29
• Purity: >99 %
• Description: Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

Product References

The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in - The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in

Wada M, Furuya Y, Sakiyama J, Kobayashi N, Miyata S, Ishii H, Nagano N. J Clin Invest. 1997 Dec 15;100(12):2977-83.

NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium - NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium

Fox J, Lowe SH, Petty BA, Nemeth EF. J Pharmacol Exp Ther. 1999 Aug;290(2):473-9.

Effect of the calcimimetic R-568 - Effect of the calcimimetic R-568

Lu JY, Yang Y, Gnacadja G, Christopoulos A, Reagan JD. J Pharmacol Exp Ther. 2009 Dec;331(3):775-86.