R 59-022

• Supplier: Tocris Bioscience
• Catalog: 3815
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 93076-89-2
• Chemical Name: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
• Formula: C27H26FN3OS
• Molecular Weight: 459.58
• Purity: >98 %
• Description: Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

Product References

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and - R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and

de Chaffoy de Courcelles DC, Roevens P, Van Belle H. J Biol Chem. 1985 Dec 15;260(29):15762-70.

A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and - A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and

Nunn DL, Watson SP. Biochem J. 1987 May 1;243(3):809-13.

Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022. - Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022.

Boonen GJ, de Koster BM, VanSteveninck J, Elferink JG. Biochim Biophys Acta. 1993 Jul 28;1178(1):97-102.

Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced - Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced

Nobe K, Miyatake M, Nobe H, Sakai Y, Takashima J, Momose K. Br J Pharmacol. 2004 Sep;143(1):166-78. Epub 2004 Aug 2.