R 7050

• Supplier: Tocris Bioscience
• Catalog: 2194
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 303997-35-5
• Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
• Formula: C16H8ClF3N4S
• Molecular Weight: 380.77
• Purity: >98 %
• Description: Inhibitor of TNF- α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF- α -induced NF- κ B and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Product References

A class of small molecules that inhibit TNFalpha-induced survival and death - A class of small molecules that inhibit TNFalpha-induced survival and death

Gururaja TL, Yung S, Ding R, Huang J, Zhou X, McLaughlin J, Daniel-Issakani S, Singh R, Cooper RD, Payan DG, Masuda ES, Kinoshita T. Chem Biol. 2007 Oct;14(10):1105-18.

TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following - TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following

King MD, Alleyne CH Jr, Dhandapani KM. Neurosci Lett. 2013 May 10;542:92-6.