R 892

Name R 892
Supplier Tocris Bioscience
Catalog 3407
Prices $209.00
Sizes 1 mg
Function Type Antagonist
Cas Number 229030-05-1
Formula C58H83N13O12
Molecular Weight 1154.37
Description Potent and selective bradykinin B 1 receptor antagonist (ID 50 values are 2.8 and > 600 nM at B 1 and B 2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo .
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Product References

Structure-activity studies of B1 receptor-related peptides. Antagonists. - Structure-activity studies of B1 receptor-related peptides. Antagonists.

Gobeil F, Neugebauer W, Filteau C, Jukic D, Allogho SN, Pheng LH, Nguyen-Le XK, Blouin D, Regoli D. Hypertension. 1996 Nov;28(5):833-9.

Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. - Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.

Duka I, Duka A, Kintsurashvili E, Johns C, Gavras I, Gavras H. Hypertension. 2003 Nov;42(5):1021-5. Epub 2003 Oct 13.