R18

Name R18
Supplier Tocris Bioscience
Catalog 3226
Prices $309.00
Sizes 1 mg
Function Type Antagonist
Cas Number 211364-78-2
Formula C101H157N27O29S3
Molecular Weight 2309.69
Description Antagonist of 14.3.3 proteins (K D ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
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Product References

Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage - Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage

Wang B, Yang H, Liu YC, Jelinek T, Zhang L, Ruoslahti E, Fu H. Biochemistry. 1999 Sep 21;38(38):12499-504.

14-3-3 proteins mediate an essential anti-apoptotic signal. - 14-3-3 proteins mediate an essential anti-apoptotic signal.

Masters SC, Fu H. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.