R-96544 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4592
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 167144-80-1
• Chemical Name: (2R,4R)-5-[2-[2-[2-(3-Methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinolhydrochloride
• Formula: C22H29NO3.HCl
• Molecular Weight: 391.94
• Purity: >99 %
• Description: Potent, selective 5-HT 2 receptor antagonist; displays some selectivity for 5-HT 2A receptors (K i = 1.6 nM). IC 50 values are 2.2, 310, 2400, 3700, > 5000 and > 5000 nM for 5-HT 2 , α 1 -adrenergic, D 2 dopamine, 5-HT 1 , 5-HT 3 and β -adrenergic receptors respectively. Inhibits 5-HT-induced platelet aggregation and pressor responses in vivo .

Product References

[2-(O-Phenylalkyl)phenoxy]alkylamines III: Synthesis and selective serotonin-2 - [2-(O-Phenylalkyl)phenoxy]alkylamines III: Synthesis and selective serotonin-2

Tanaka N, Goto R, Ito R, Hayakawa M, Sugidachi A, Ogawa T, Asai F, Fujimoto K. Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1729-39.

Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor - Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor

Ogawa T, Sugidachi A, Tanaka N, Fujimoto K, Asai F. Eur J Pharmacol. 2002 Dec 20;457(2-3):107-14.

Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor - Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor

Ogawa T, Sugidachi A, Tanaka N, Fujimoto K, Fukushige J, Tani Y, Asai F. Eur J Pharmacol. 2005 Oct 3;521(1-3):156-63. Epub 2005 Sep 22.