Radicicol

• Supplier: Tocris Bioscience
• Catalog: 5252
• Prices: $129.00
• Sizes: 1 mg
• Cas Number: 12772-57-5
• Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
• Formula: C18H17ClO6
• Molecular Weight: 364.78
• Purity: >98 %
• Description: Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Product References

Radicicol, a microbial cell differentiation modulator, inhibits in vivo - Radicicol, a microbial cell differentiation modulator, inhibits in vivo

Oikawa T, Ito H, Ashino H, Toi M, Tominaga T, Morita I, Murota S. Eur J Pharmacol. 1993 Sep 14;241(2-3):221-7.

Interaction of radicicol with members of the heat shock protein 90 family of - Interaction of radicicol with members of the heat shock protein 90 family of

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV. Mol Endocrinol. 1999 Sep;13(9):1435-48.

Radicicol represses the transcriptional function of the estrogen receptor by - Radicicol represses the transcriptional function of the estrogen receptor by

Lee MO, Kim EO, Kwon HJ, Kim YM, Kang HJ, Kang H, Lee JE. Mol Cell Endocrinol. 2002 Feb 25;188(1-2):47-54.