RAF 265

• Supplier: Tocris Bioscience
• Catalog: 1589
• Prices: $215.00, $905.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 927880-90-8
• Chemical Name: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
• Formula: C24H16F6N6O
• Molecular Weight: 518.41
• Purity: >98 %
• Description: Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Product References

Anti-allodynic effect of NW-1029, a novel Na(+) channel blocker, in experimental - Anti-allodynic effect of NW-1029, a novel Na(+) channel blocker, in experimental

Veneroni O, Maj R, Calabresi M, Faravelli L, Fariello RG, Salvati P. Pain. 2003 Mar;102(1-2):17-25.

Effects of ralfinamide, a Na+ channel blocker, on firing properties of - Effects of ralfinamide, a Na+ channel blocker, on firing properties of

Yamane H, de Groat WC, Sculptoreanu A. Exp Neurol. 2007 Nov;208(1):63-72. Epub 2007 Jul 19.

Ralfinamide administered orally before hindpaw neurectomy or postoperatively - Ralfinamide administered orally before hindpaw neurectomy or postoperatively

Zhang SH, Blech-Hermoni Y, Faravelli L, Seltzer Z. Pain. 2008 Oct 15;139(2):293-305.