Raloxifene hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4029
• Prices: $89.00
• Sizes: 50 mg
• Function Type: Modulator
• Cas Number: 82640-04-8
• Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanonehydrochloride
• Formula: C28H27NO4S.HCl
• Molecular Weight: 510.04
• Purity: >98 %
• Description: Selective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM.

Product References

Effect of estrogen agonists and antagonists on induction of progesterone receptor - Effect of estrogen agonists and antagonists on induction of progesterone receptor

Fitzpatrick SL, Berrodin TJ, Jenkins SF, Sindoni DM, Deecher DC, Frail DE. Endocrinology. 1999 Sep;140(9):3928-37.

Mechanism of action and preclinical profile of raloxifene, a selective estrogen - Mechanism of action and preclinical profile of raloxifene, a selective estrogen

Bryant HU. Rev Endocr Metab Disord. 2001 Jan;2(1):129-38.