Ramipril

• Supplier: Tocris Bioscience
• Catalog: 2280
• Prices: $105.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 87333-19-5
• Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylicacid
• Formula: C23H32N2O5
• Molecular Weight: 416.51
• Purity: >99 %
• Description: Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC 50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Product References

Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush - Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush

Stevens BR, Phillips MI, Fernandez A. Comp Biochem Physiol C. 1988;91(2):493-7.

Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril - Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril

Levitt DG, Schoemaker RC. BMC Clin Pharmacol. 2006 Jan 6;6:1.

Ramipril protects the endothelium from high glucose-induced dysfunction through - Ramipril protects the endothelium from high glucose-induced dysfunction through

Tian S, Ge X, Wu K, Yang H, Liu Y. J Pharmacol Exp Ther. 2014 Jul;350(1):5-13.