Ranolazine dihydrochloride

Name Ranolazine dihydrochloride
Supplier Tocris Bioscience
Catalog 1967
Prices $115.00
Sizes 50 mg
Function Type Inhibitor
Cas Number 95635-56-6
Chemical Name N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamidedihydrochloride
Formula C24H33N3O4.2HCl
Molecular Weight 500.46
Purity >98 %
Description Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.
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Product References

Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct - Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct

Zacharowski K, Blackburn B, Thiemermann C. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.

Inhibition of late sodium current to reduce electrical and mechanical dysfunction - Inhibition of late sodium current to reduce electrical and mechanical dysfunction

Shryock JC, Belardinelli L. Br J Pharmacol. 2008 Mar;153(6):1128-32. Epub 2007 Dec 10.

Antitorsadogenic effects of - Antitorsadogenic effects of

Wang WQ, Robertson C, Dhalla AK, Belardinelli L. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.