Rapamycin

Name Rapamycin
Supplier Tocris Bioscience
Catalog 3118
Prices $259.00
Sizes 1 mg
Cas Number 53123-88-9
Chemical Name (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Formula C51H79NO13
Molecular Weight 914.18
Purity >98 %
Description Antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase. Induces autophagy in yeast and mammalian cell lines. Drives hPSC differentiation to mesendoderm and blood progenitor cells. Also used as a chemical dimerizer; rapamycin and GA 3 -AM (Cat. No. 5407) chemically inducible dimerization systems are orthogonal.
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Product References

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. - Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.

Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. Nature. 1992 Jul 2;358(6381):70-3.

Rapamycins: mechanism of action and cellular resistance. - Rapamycins: mechanism of action and cellular resistance.

Huang S, Bjornsti MA, Houghton PJ. Cancer Biol Ther. 2003 May-Jun;2(3):222-32.

Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses - Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses

Kobayashi S, Kishimoto T, Kamata S, Otsuka M, Miyazaki M, Ishikura H. Cancer Sci. 2007 May;98(5):726-33.

Chemical modulators of autophagy as biological probes and potential therapeutics. - Chemical modulators of autophagy as biological probes and potential therapeutics.

Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Nat Chem Biol. 2011 Jan;7(1):9-17.