Remacemide hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3284
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 111686-79-4
• Chemical Name: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamidehydrochloride
• Formula: C17H20N2O.HCl
• Molecular Weight: 304.82
• Purity: >99 %
• Description: Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).

Product References

Neuroprotective properties of the uncompetitive NMDA receptor antagonist - Neuroprotective properties of the uncompetitive NMDA receptor antagonist

Palmer GC, Cregan EF, Borrelli AR, Willett F. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248.

Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine - Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine

Subramaniam S, Donevan SD, Rogawski MA. J Pharmacol Exp Ther. 1996 Jan;276(1):161-8.

Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical - Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical

Santangeli S, Sills GJ, Thompson GG, Brodie MJ. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8.