RepSox

• Supplier: Tocris Bioscience
• Catalog: 3805
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 446859-33-2
• Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
• Formula: C17H13N5
• Molecular Weight: 287.32
• Purity: >99 %
• Description: Potent and selective inhibitor of the TGF- β type I receptor/ALK5 (IC 50 values are 4 and 23 nM for TGF- β type I receptor autophosphorylation and binding respectively). Selective for TGF- β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC 50 > 16 μ M). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

Product References

Identification of 1,5-naphthyridine derivatives as a novel series of potent and - Identification of 1,5-naphthyridine derivatives as a novel series of potent and

Gellibert F, Woolven J, Fouchet MH, Mathews N, Goodland H, Lovegrove V, Laroze A, Nguyen VL, Sautet S, Wang R, Janson C, Smith W, Krysa G, Boullay V, De Gouville AC, Huet S, Hartley D. J Med Chem. 2004 Aug 26;47(18):4494-506.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming - A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming

Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. Cell Stem Cell. 2009 Nov 6;5(5):491-503.

Generation of rat and human induced pluripotent stem cells by combining genetic - Generation of rat and human induced pluripotent stem cells by combining genetic

Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H, Ding S. Cell Stem Cell. 2009 Jan 9;4(1):16-9.