Resiquimod

Name	Resiquimod
Supplier	Tocris Bioscience
Catalog	1137
Prices	$89.00, $345.00
Sizes	10 mg, 50 mg
Function Type	Agonist
Cas Number	144875-48-9
Chemical Name	1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Formula	C17H22N4O2
Molecular Weight	314.38
Purity	>98 %
Description	Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN- γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
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Product References

Modulation of TH1 and TH2 cytokine production with the immune response modifiers, - Modulation of TH1 and TH2 cytokine production with the immune response modifiers,

Wagner TL, Ahonen CL, Couture AM, Gibson SJ, Miller RL, Smith RM, Reiter MJ, Vasilakos JP, Tomai MA. Cell Immunol. 1999 Jan 10;191(1):10-9.

Imiquimod and resiquimod as novel immunomodulators. - Imiquimod and resiquimod as novel immunomodulators.

Dockrell DH, Kinghorn GR. J Antimicrob Chemother. 2001 Dec;48(6):751-5.

R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not - R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not

Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamachi T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R. Cytotechnology. 2012 May;64(3):331-9.