RHC 80267

• Supplier: Tocris Bioscience
• Catalog: 3498
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 83654-05-1
• Chemical Name: O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
• Formula: C20H34N4O4
• Molecular Weight: 394.51
• Purity: >95 %
• Description: Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).

Product References

Relative activities of rat and dog platelet phospholipase A2 and diglyceride - Relative activities of rat and dog platelet phospholipase A2 and diglyceride

Sutherland CA, Amin D. J Biol Chem. 1982 Dec 10;257(23):14006-10.

Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of - Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of

Suzuki H, Kito Y, Fukuta H, Yamamoto Y. J Smooth Muscle Res. 2002 Dec;38(6):153-64.

The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to - The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to

Ghisdal P, Vandenberg G, Hamaide MC, Wibo M, Morel N. Eur J Pharmacol. 2005 Jul 4;517(1-2):97-102.