Rhosin hydrochloride

Name Rhosin hydrochloride
Supplier Tocris Bioscience
Catalog 1842
Prices $95.00, $399.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1281870-42-5
Chemical Name D-Tryptophan(2E)-2-(6-quinoxalinylmethylene)hydrazidehydrochloride
Formula C20H18N6O.HCl
Molecular Weight 394.86
Purity >98 %
Description Rho GTPase inhibitor (K d = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro . Also induces neurite outgrowth in synergy with NGF.
Supplier Page Shop

Product References

Rational design of small molecule inhibitors targeting RhoA subfamily Rho - Rational design of small molecule inhibitors targeting RhoA subfamily Rho

Shang X, Marchioni F, Sipes N, Evelyn CR, Jerabek-Willemsen M, Duhr S, Seibel W, Wortman M, Zheng Y. Chem Biol. 2012 Jun 22;19(6):699-710.

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide - Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide

Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60. doi: