Rimcazole dihydrochloride

Name Rimcazole dihydrochloride
Supplier Tocris Bioscience
Catalog 0768
Prices $165.00, $685.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 75859-03-9
Chemical Name 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazoledihydrochloride
Formula C21H27N3.2HCl
Molecular Weight 394.39
Purity >98 %
Description Antagonist at σ receptors (IC 50 values are 1480 and 386 nM at σ 1 and σ 2 receptors respectively). Also binds to the dopamine transporter (IC 50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo .
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Product References

Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a - Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a

Ferris RM, Tang FL, Chang KJ, Russell A. Life Sci. 1986 Jun 23;38(25):2329-37.

Isothiocyanate derivatives of - Isothiocyanate derivatives of

Husbands SM, Izenwasser S, Loeloff RJ, Katz JL, Bowen WD, Vilner BJ, Newman AH. J Med Chem. 1997 Dec 19;40(26):4340-46.

Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with - Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with

Matsumoto RR, Hewett KL, Pouw B, Bowen WD, Husbands SM, Cao JJ, Newman AH. Neuropharmacology. 2001 Dec;41(7):878-86.