RITA

• Supplier: Tocris Bioscience
• Catalog: 5538
• Prices: $95.00, $199.00
• Sizes: 1 mg, 10 mg
• Cas Number: 213261-59-7
• Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
• Formula: C14H12O3S2
• Molecular Weight: 292.37
• Purity: >97 %
• Description: Anti-tumor agent that binds wild-type p53 (K d = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo . Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo .

Product References

Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell - Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell

Rivera MI, Stinson SF, Vistica DT, Jorden JL, Kenney S, Sausville EA. Biochem Pharmacol. 1999 Jun 1;57(11):1283-95.

Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking - Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking

Zhao CY, Szekely L, Bao W, Selivanova G. Cancer Res. 2010 Apr 15;70(8):3372-81.