RJR 2429 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1053
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1021418-53-0
• Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octanedihydrochloride
• Formula: C12H16N2.2HCl
• Molecular Weight: 261.19
• Purity: >98 %
• Description: Potent nAChR agonist that displays selectivity for α 4 β 2 (K i = 1 nM) and α 1 βγδ subtypes (EC 50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC 50 = 2 nM) and inhibits ion flux in thalamic neurons (IC 50 = 154 nM). Also putative α 3 β 4 agonist that potentiates catecholamine release.

Product References

The heterocyclic substituted pyridine derivative - The heterocyclic substituted pyridine derivative

Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, Fowler K, Reeves L, Lippiello PM. J Pharmacol Exp Ther. 1998 Mar;284(3):886-94.

Characterization of functional nicotinic acetylcholine receptors involved in - Characterization of functional nicotinic acetylcholine receptors involved in

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Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, - Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane,

Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. J Org Chem. 2008 May 2;73(9):3497-507.