| Name | RKI 1447 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1271 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Chemical Name | N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]ureadihydrochloride |
| Formula | C16H14N4O2S.2HCl |
| Molecular Weight | 399.29 |
| Purity | >99 % |
| Description | Potent and selective ROCK inhibitor (IC 50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells. |
| Supplier Page | Shop |
Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schonbrunn E, Lawrence NJ, Sebti SM. Cancer Res. 2012 Oct 1;72(19):5025-34.
Pireddu R, Forinash KD, Sun NN, Martin MP, Sung SS, Alexander B, Zhu JY, Guida WC, Schonbrunn E, Sebti SM, Lawrence NJ. Medchemcomm. 2012 Jun 1;3(6):699-709. Epub 2012 Jan 27.